Resumo

CALLAPA, JORGIA et al. Epidemiological, serological and molecular study of the chagas disease in the bolivian amazon. Rev.Cs.Farm. y Bioq. [online]. 2018, vol.6, n.1, pp. 83-96. ISSN 2310-0265.

Abstract The present study is part of the project PIA-ACC.UMSA.01 "Search for New EndemicAreas of Chagas Disease in the Bolivian Amazon as an effect of Climate Change", which has allowed us to carry out the epidemiological - serological and molecular study of Chagas disease in as-ymptomatic people living in six regions of the Bolivian Amazon: Riberalta; Guayaramerín; Cobija; Trinidad; San Joaquín and San Borja, who in their majority belonged to the diverse in-digenous towns, affected by the poverty. Clini-cal exploration and serological and molecular diagnostic tests of Chagas disease were per-formed on the population of each region at no cost The participation of the people was co-ordinated with the Central de Pueblos Indígenas del Beni (Central de Pueblos Indígenas del Beni) and by signing the informed consent all the volunteer participants were submitted to the study. A total of 338 samples were processed with the ELISA serological tests; HAI and IFI and the molecular test of the PCR at the end point The seropositivity was 6.2% (21 cases) and the PCR was positive in 3.8% (13 cases). Of the total positive Chagas cases, 42% were cases of migrants from endemic regions such as Cochabamba, Santa Cruz, Chuquisaca and Yungas de La Paz. Likewise, the main risk factors asso-ciated with the disease were identified, noting among other aspects that inhabitants of these regions have little knowledge about Chagas disease; however, they are aware of the appearance of strange diseases in these regions due to the climatic variations detected in recent years and evidence their concern about the negative ef-fects of climate change

Palavras-chave : Chagas Disease; Bolivian Amazon; Diagnosis; Epidemiology.