Abstract

GUZMAN-DUCHEN, Héctor; ARAOZ-ILLANES, Reynaldo  and  VIRHUEZ-SALGUERO, Yblin Katherine. PROGRESSIVE MULTIFOCAL LEUKOENCEPHALOPATHY: APROPOS OFA CASE. Rev. Méd.-Cient. Luz Vida [online]. 2011, vol.2, n.1, pp. 72-75. ISSN 2219-8032.

Progressive Multifocal Leukoencephalopathy is a disease caused by a polimixovirus JC, which are the initials of the first patient which was diagnosed. this disease causes demyelization of cerebral white matter in immunocompromised patients. It is the case of a 42-year-old man who comes to the hospital for yellowish liquid feaces with weight loss of approximately 20 kg and a productive cough for about a year and a half of evolution, which is admitted with the following diagnostic impressions: Tuberculosis, HIV-AIDS and chronic gastroenteritis. The evolution of the patient's general condition was unfavorable due to the detection of progressive multifocal leukoencephalopathy, and other concomitant infections such as meningeal criptoccocosis. There is currently no effective treatment, but studies have searched some treatments in vitro with Mefloquine and Mirtuzapina for their effect against JC virus. It also highlights the importance of molecular biology techniques including the polymerase chain reaction for diagnosis, determining the presence of the JC virus, directly linked to the disease. It is said that PCR, NMR with typical injuries and clinical context leads the diagnosis in 92-100%.

Keywords : Progressive multifocal leukoencephalopathy; JC virus; Infections in HIV-AIDS.