Abstract

CARPIO-DEHEZA, Gonzalo; VARGAS-VEGA, Ana Lía; JAILLITA-MENESES, Cristhian  and  FLORES-VILLARROEL, Cristhian. COMPARATIVE STUDY OF TOCOLYTIC ACTIONS AND SIDE EFFECTS OF NIFEDIPINE VERSUS RITODRINE ABOUT THE TREATMENT OFPRETERMBIRTH,"HOSPITAL MATERNO INFANTIL GERMÁN URQUIDI". Rev. Méd.-Cient. Luz Vida [online]. 2011, vol.2, n.1, pp. 21-26. ISSN 2219-8032.

Background: The tocolytic treatment in preterm labor threat has become the basis of management. Its main objective is to delay the birth. This would permit to complete the scheme of lung ma-turation. In addition this treatment reduces morbidity and perinatal mortality associated with prematurity. Objective: It is to evaluate the efficacy/effectiveness of Nifedipi-ne and Ritodrine as tocolytic agents in patients with preterm labor threat in Hospital Materno-Infantil Germán Urquidi (HMIGU) du-ring the period of September to December 2010. Methods: It is an, analytical, descriptive, retro-prospective, and longitudinal research where the sample population was: pregnant patients admitted to HMIGU with the diagnosis of preterm labor threat, which fulfill the inclusion criteria. Results: Ritodrine presents more general alterations (headache, nausea and vomiting), the relationship was 1.5-4:1 versus Nifedi-pine. Talking about hypotension as side effect, Ritodrine presented more cases in a ratio of 1.7:1 to Nifedipine. Finally, in terms of side effects on the fetus. It was observed variations in fetal heart rate. there was a significant tachy cardia of more than 10-20 beats per minute compared to baseline. This happened in 25% of women treated with Ritodrine versus 10% of women treated with Nifedipine. Conclusion: Nifedipine proved to be an effective utero inhibition drug between 24-34 weeks, presenting minimal side effects in patients without premature rupture of membranes, nor associated di-sease. In addition, it had a very good cost-benefit ratio respect to Ritodrine.

Keywords : Tocolytic Actions; Nifedipine versus Ritodrine; Teatment of preterm birth.