Resumen

GUTIERREZ YAPU, David; SANGAMA MOZOMBITE, Diana; RENGIFO SALGADO, Elsa  y  GIMENEZ TURBA, Alberto. Evaluación de la actividad antiplasmódica in vitro de extractos de Euterpe oleracea, Myrciaria dubia  y Croton lechleriEvaluation of the in vitro antiplasmodic activity of extracts from Euterpe oleracea, Myrciaria dubia and Croton lechleri. BIOFARBO [online]. 2008, vol.16, n.1, pp. 16-20. ISSN 1813-5363.

The malaria disease continues  to be a problem of public health at world level, particularly in underdeveloped countries with tropical zones in their geography, as it is the case of the amazonian region of Sud America. Malaria, leishmaniasis and Chagas, are diseases closely linked  to poverty reasons, and that is why, for us to control them,  the world-wide public health organizations compelled in the eradication of malaria desease have created strategies for an opportune antimalarial treatment. One of the main obstacles that aggravate the situation of this disease and its eradication is the development of the resistance from Plasmodium strains  in relation to antimalarial drugs of election. Another problem is the development of the resistance from the mosquito vector in relation to insecticides used for its elimination and prevention in the transmission. This work has as its main objective to look for new alternatives for the treatment of malaria, taking advantage of the existence of diverse plants used in terms of the traditional medicine in the amazonian region  of Peru and Bolivia. The antiplasmodic activity of 27 extracts corresponding to 9 vegetal, originating species of the Peruvian Amazonia was studied. These were evaluated on Plasmodium falciparum basis (resistant strain  FCR3 to the chloroquine) through the direct visual method, and it is necessary to mention that this strain was maintained through the in vitro continuous culture method. The dichloromethanic and ethanolic extract of Euterpe oleracea had a CI₅₀ of 3 and 5 µg/mL respectively, the CI₅₀ of watery and ethanolic extract of Myrciaria dubia had value of 3 and  6 µg/mL respectively and the watery extract of Croton lechleri had a  CI₅₀ and was  2 µg/mL. It was two vegetal species which presented activity with two types of extract, this fact represents a major probability that these species present compounds with antiplasmodic activity

Palabras llave : Plasmodium falciparum; Amazonian; Antimalaric plants; Euterpe oleracea; Myrciaria dubia; Croton lechleri.