Resumen

MAMANI JARRO, Josué'  y  PATTI VILA, Lidia Elena. Papel del Factor Inducido por la Hipoxia-1(HIF-1) y Eritropoyetina en la preeclampsia. SCIENTIFICA [online]. 2011, vol.9, n.1, pp. 39-45. ISSN 1813-0054.

ABSTRACT Preeclampsia is defined as a systemic disease characterized by hemodynamic alterations that are manifested from the second trimester of pregnaney, which are called eclampsia when hypertension is associated with scizures and / or coma. There is an incrcased number of women with preeclampsia at high altitude regions compared with regions located at sea level. Have suggested that environmental hypoxia resiilting from reduced oxygen pressure would be a predisposing factor for development of prceclampsia, because of the direct relationship between levéis of hypoxia inducible factor-1 (HIF-1) and hemodynamic changes such as hypertension. reducing the diameter of the uterine artery, reducing blood flow through the uterine artery, and intrauterine growth restriction, present in preeclampsia. The factor induced by hypoxia produces these effeets through the increased expression of erythropoietin (Epo), a hormonc that produces alterations in the expression of vasodilator and vasoconstrictor agents: reduced production of nitric oxide (NO) and catkin biosynthesis endothelin-1 (ET-1), this action would be the cause of the increased incidenee of preeclamptic women in high altitude residents have higher levéis of HIF-la and EPO in relation to pregnant women living at sea level and this is the foundation to propose to HIFla as an early biomarker of risk of preeclampsia.

Palabras llave : Factor induced for the -1 ; hypoxia; Erythropoietin; Hypoxia; Preeclampsia; Biological marker.