Resumo

RODAS, Claudia; HALVORSEN, Kjetil  e  INIGUEZ, Volga. Multiresistencia antimicrobiana asociada a integrones en enteropatógenos de la diarrea infantil y Escherichia coli de la flora normal en niños menores de 5 años en la ciudad de La Paz. Cuad. - Hosp. Clín. [online]. 2005, vol.50, n.2, pp. 38-48. ISSN 1652-6776.

A total of 138 samples collected in the city of La Paz, including enteropathogens isolated from stools of children with diarrhea as well as fecal E. coli from healthy children, were analyzed to evalúate integron-associated antimicrobial multi-resistance distribution. The highest rate of resistance was against Ampicillin (95%), Streptomycin (90%) followed by Cotrimoxazole (60%). A high percentage (96%) of antimicrobial resistance isolates to at least one antibiotic and multi-resistance to between 3-6 antibiotics (82%) was found. Resistance patterns were similar among Shigella spp and non-diarrheogenic E coli, showing high multi-resistance prevalence to ( 4 antibiotics, in contrast to ETEC and EPEC. These data suggest, that non-diarrheogenic E coli can serve as multi-resistance genes reservoir to other pathogens and vice versa, and that multi-resistance expansion may be associated with the circulating enteropathogens prevalence. In all isolates, a significant association among class 2 integran and (4 antibiotic multi-resistance was found, as well as between class 1 integron and isolates from Shigella and non-diarrheogenic E coli. Integran presence was associated with the resistance to 7 antibiotics. This is the first report of molecular detection of integrons among pathogenic and normal flora of child population of city of La Paz demonstrating a wide integron-associated antimicrobial multi-resistance. These results are relevant to antimicrobial diarrhea treatment and resistance dissemination control.

Palavras-chave : Antibiotic multiresistance; Int (integron); enteropathogen; E. coli ND (E. coli non diarrheogenic); EPEC (E. coli enteropathogenic); ETEC (E. coli enterotoxigen); EHEC (E. coli enterohemorragic).