Abstract

ARANCIBIA ANDRADE, Boris; MARIN MOSCOSO, Katerine; CHOQUE BEJARANO, Alexander  and  ORTUSTE IBANEZ, Cimar. Toxic epidermal necrolysis (lyell syndrome) induced by phenobarbital. Acase report. Arch.Boliv.Med. [online]. 2018, vol.30, n.98, pp. 48-55. ISSN 0004-0525.

Stevens Johnson Syndrome (SJS) is considered to be the initial stage of a skin reaction whose most severe form of presentation is Toxic Epidermal Necrolysis (TEN). Table characterized histologically by necrosis of the epidermis and clinically by a diffuse epidermolysis, with exfoliation, in addition to non-cutaneous manifestations, which causes hydroelectrolytic disorders, thermoregulation and hypercatabolism, 80% of cases are produced by a drug. We describe the clinical case of a 56-year-old male patient with a history of CVA secondary encephalocutaneous trauma, for which he was medicated with phenobarbital receiving the medication for 14 days, he went to the emergency service of the Hospital Santa Barbará for presenting headache, edema facial, generalized pruritic lesions on the skin maculo paula erythematosus type. During the hospitalization, the skin lesions increased with diffuse epidermolysis, with exfoliation or formation of bullous lesions, until toxic epidemic necrolysis was established, with hemodynamic support, hydration, corticosteroids and balneotherapy with favorable evolution

Keywords : Stevens Johnson Syndrome; Toxic epidermal necrolysis; Fenobarbital; Toxic drug reactions.