Resumo

CANEDO GUTIERREZ, Alejandra Denis  e  MOSCOSO ZEBALLOS, Pablo Alejandro. Alzheimer prevention: neuroprotective effect of docosahexaenoic acid (DHA) in neuronal plasma membranes. SCIENTIFICA [online]. 2013, vol.11, n.1, pp. 35-41. ISSN 1813-0054.

ABSTRACT Alzheimer's disease (AD) is a progressive dementia that manifests itself early with the loss of synaptic functions and capacity of storage of the individual. Statistical studies show that 5% of people bordering 65 already have symptoms of the EA as well as 50% of people who skirt the 85 years. The molecular basis of the EA are still unknown but we know the forerunner of development, the peptide p -amyloid (BA); this occurs during proteolysis specifies that it occurs after the synthesis and processing of the precursor protein amyloid (PPA), causing three products: 1-40, 1-42 BA BA and the P-3 of which the only toxic is the BA 1-42. The accumulation of this BA is produced by increased production or debugging decreased forming senile plaques, one of the characteristic neuropatologicas of the EA. DHA (Docosahexaenoic acid) is an omega 3 unsaturated poly, long-chain fatty acid (22:6n - 3), which is present in all tissues of the body and which arises naturally liquid and is maintained in this way even at low temperatures. DHA is an important structural and functional element of all the membranes of the cells that make up the gray matter of the brain, so it plays a prominent role in neural development. That's why in this review analyzed the possible effect of DHA on neuronal plasma membranes as a way of nutritional prevention forthe AD.

Palavras-chave : DHA; neuroprotection; nutrition; Alzheimer's disease; amyloid peptide.